Clopidogrel treatment during pregnancy: a case report and a review of literature

Intern Med. 2011;50(16):1769-73. doi: 10.2169/internalmedicine.50.5294. Epub 2011 Aug 15.


Management of ischemic heart disease in pregnant women is still difficult, as there is little experience with many of the newer treatments such as clopidogrel. The safety of clopidogrel in pregnancy is unknown, especially in combination with aspirin. Its use during gestation has been described in a few case reports. We describe the case of a 36-year-old woman in her 9th week of pregnancy with a history of chronic hypertension, dyslipidemia and CAD, who required antiplatelet treatment. Clopidogrel and aspirin were administrated until one week before delivery and a healthy child was born at 36 weeks of pregnancy by caesarean section, without any complication.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Clopidogrel
  • Female
  • Humans
  • Infant, Newborn
  • Myocardial Ischemia / drug therapy*
  • Myocardial Ischemia / physiopathology
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / drug therapy*
  • Pregnancy Complications, Cardiovascular / physiopathology
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / therapeutic use
  • Treatment Outcome


  • Clopidogrel
  • Ticlopidine