Delayed cardiac metastasis from phyllodes breast tumor presenting as cardiogenic shock

Tex Heart Inst J. 2011;38(4):441-4.

Abstract

Malignant metastases to the heart and pericardium, which occur far more often than do primary cardiac neoplasms, typically lead to fatal outcomes. The phyllodes tumor is a rare, predominantly benign fibroepithelial breast neoplasm with variable malignancy potential. Herein, we describe the case of a 35-year-old woman who, 3 years after undergoing a simple mastectomy for a rapidly enlarging breast neoplasm, presented with cardiogenic shock and was found to have a large right ventricular tumor that obstructed the right ventricular outflow tract. Despite successful resection of the ventricular mass and a right atrial mass of organized thrombus, the patient died 8 days postoperatively of multiorgan failure due to severe right ventricular dysfunction. Histopathologic analysis determined that the right ventricular mass was a malignant, metastatic phyllodes tumor. To our knowledge, this is only the 2nd reported case of a phyllodes tumor that metastasized to the heart and presented as an intracavitary mass with cardiogenic shock. In addition to discussing our patient's case, we review the pertinent medical literature.

Keywords: Breast neoplasms/pathology; cardiac surgical procedures; electrocardiography; fatal outcome; heart neoplasm metastasis; heart ventricles; neoplasm invasiveness; neoplasms/secondary/surgery; phyllodes tumor/pathology/secondary/surgery; recurrence.

Publication types

  • Case Reports
  • Review
  • Video-Audio Media

MeSH terms

  • Adult
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / surgery
  • Cardiac Surgical Procedures
  • Echocardiography, Transesophageal
  • Female
  • Heart Neoplasms / complications*
  • Heart Neoplasms / diagnosis
  • Heart Neoplasms / secondary*
  • Heart Neoplasms / surgery
  • Heart Ventricles / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Mastectomy
  • Phyllodes Tumor / secondary*
  • Phyllodes Tumor / surgery
  • Shock, Cardiogenic / diagnosis
  • Shock, Cardiogenic / etiology*
  • Shock, Cardiogenic / surgery
  • Time Factors
  • Treatment Outcome
  • Ventricular Outflow Obstruction / etiology