Protein-directed one-pot synthesis of Ag microspheres with good biocompatibility and enhancement of radiation effects on gastric cancer cells

Peng Huang; Da-Peng Yang; Chunlei Zhang; Jing Lin; Meng He; Le Bao; Daxiang Cui

doi:10.1039/c1nr10586h

Protein-directed one-pot synthesis of Ag microspheres with good biocompatibility and enhancement of radiation effects on gastric cancer cells

Nanoscale. 2011 Sep 1;3(9):3623-6. doi: 10.1039/c1nr10586h. Epub 2011 Aug 15.

Authors

Peng Huang¹, Da-Peng Yang, Chunlei Zhang, Jing Lin, Meng He, Le Bao, Daxiang Cui

Affiliation

¹ Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, National Key Laboratory of Micro/Nano Fabrication Technology, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China.

PMID: 21842073
DOI: 10.1039/c1nr10586h

Abstract

Biocompatible Ag@BSA microspheres were successfully synthesized via one-pot reaction in aqueous phase at room temperature by using BSA as soft templates. The individual Ag microsphere is composed of nanoscale Ag assemblies and shows enhanced radiation effects on gastric cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials / chemistry*
Biocompatible Materials / toxicity
Cattle
Cell Line, Tumor
Circular Dichroism
Humans
Metal Nanoparticles / chemistry*
Metal Nanoparticles / toxicity
Metal Nanoparticles / ultrastructure
Microspheres*
Photosensitizing Agents / therapeutic use
Serum Albumin, Bovine / chemistry*
Silver / chemistry*
Stomach Neoplasms / radiotherapy
Temperature
X-Rays

Substances

Biocompatible Materials
Photosensitizing Agents
Serum Albumin, Bovine
Silver