Near-real time oculodynamic MRI: a feasibility study for evaluation of diplopia in comparison with clinical testing

Eur Radiol. 2012 Feb;22(2):358-63. doi: 10.1007/s00330-011-2232-1. Epub 2011 Aug 14.


Objective: To demonstrate feasibility of near-real-time oculodynamic magnetic resonance imaging (od-MRI) in depicting extraocular muscles and correlate quantitatively the motion degree in comparison with clinical testing in patients with diplopia.

Methods: In 30 od-MRIs eye movements were tracked in the horizontal and sagittal plane using a a TrueFISP sequence with high temporal resolution. Three physicians graded the visibility of extraocular muscles by a qualitative scale. In 12 cases, the maximal monocular excursions in the horizontal and vertical direction of both eyes were measured in od-MRIs and a clinical test and correlated by the Pearson test.

Results: The medial and lateral rectus muscles were visible in the axial plane in 93% of the cases. The oblique, superior and inferior rectus muscles were overall only in 14% visible. Horizontal (p = 0,015) and vertical (p = 0,029) movements of the right eye and vertical movement of the left eye (p = 0,026) measured by od-MRI correlated positively to the clinical measurements.

Conclusions: Od-MRI is a feasible technique. Visualization of the horizontal/vertical rectus muscles is better than for the superior/inferior oblique muscle. Od-MRI correlates well with clinical testing and may reproduce the extent of eye bulb motility and extraocular muscle structural or functional deteriorations. Key Points • Oculodynamic MRI technique helps clinicians to assess eye bulb motility disorders • MRI evaluation of eye movement provides functional information in cases of diplopia • Oculodynamic MRI reproduces excursion of extraocular muscles with good correlation with clinical testing • Dynamic MRI sequence supplements static orbital protocol for evaluation of motility disorders.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Diplopia / diagnosis*
  • Diplopia / pathology*
  • Eye Movements
  • Feasibility Studies
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging, Cine / methods
  • Middle Aged
  • Models, Statistical
  • Movement
  • Ocular Motility Disorders / diagnosis
  • Ocular Motility Disorders / pathology*
  • Oculomotor Muscles / pathology*
  • Orbit / pathology*
  • Reproducibility of Results