Productive interactions among patients, friends/family, and health care providers, as outlined by the Chronic Care Model, are important for promoting adherence to recommended care and good health outcomes among adults with a chronic illness. Characteristics of these interactions--active participation, collaboration, and data sharing among constituents--are the same as those of social networks organized around Web 2.0 principles and technology. Thus, the Web 2.0 framework can be used to configure social networks without the inherent spatiotemporal constraints of face-to-face interactions that remain prevalent in health care delivery. In this article, the author outlines various design principles and decisions for a pilot study in which cellular technology was used to mediate interactions between adults with Type 2 diabetes and supporters (i.e., family members or friends selected by the patients who agree provide support) to motivate regular self-monitoring of blood glucose (among the diabetes participants). Participants generally found the network to be relatively easy to use. Some diabetes patients reported improved attention to self-monitoring; and, patient-selected supporters indicated improvements in emotional and instrumental support that should benefit diabetes patients' lifestyle and health.