The Association Between ACE Polymorphism and Risk of Colorectal Cancer in a Chinese Population

Clin Biochem. 2011 Oct;44(14-15):1223-6. doi: 10.1016/j.clinbiochem.2011.07.016. Epub 2011 Aug 6.

Abstract

Objectives: Angiotensin I-converting enzyme (ACE) plays crucial roles not only in the regulation of circulatory homeostasis but also in the pathology of carcinomas. An insertion-deletion (I/D) polymorphism in intron 16 of ACE gene was identified to be functional. We aimed to investigate the association between ACE I/D polymorphism and risk of colorectal cancer (CRC).

Design and methods: Using genomic DNA from 241 CRC patients and 299 control subjects, we genotyped the ACE I/D polymorphism using a polymerase chain reaction analysis.

Results: We found that patients carrying the D allele were associated with an increased risk of developing poorly differentiated cancer and metastasis compared with those carrying the I allele (OR=1.54, 95%CI, 1.04-2.28; OR=1.56, 95%CI, 1.08-2.26, respectively), although no significant association was observed between cases and controls in overall analysis.

Conclusions: These findings indicate that the ACE I/D polymorphism is likely to play a role in CRC progression.

MeSH terms

  • Aged
  • Asian Continental Ancestry Group / genetics*
  • Case-Control Studies
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Genetic*

Substances

  • Peptidyl-Dipeptidase A