Serum unconjugated bisphenol A concentrations in men may influence embryo quality indicators during in vitro fertilization

Environ Toxicol Pharmacol. 2011 Sep;32(2):319-23. doi: 10.1016/j.etap.2011.06.003. Epub 2011 Jul 8.


Here we assess bisphenol A (BPA) in couples undergoing in vitro fertilization (IVF) and indicators of embryo quality; embryo cell number (ECN) and embryo fragmentation score (EFS). Twenty-seven couples provided serum on the day of oocyte retrieval. Unconjugated BPA was measured by HPLC with Coularray detection. Odds ratios (OR) were generated using ordinal logistic regression including female and male BPA concentrations, age and race, and day of embryo transfer for ECN. Inverse associations are suggested for male BPA with ECN (OR=0.70, P=0.069), and EFS (OR=0.54, P=0.009), but not for women. Male BPA exposure may affect embryo quality during IVF.

MeSH terms

  • Adult
  • Benzhydryl Compounds
  • Embryo, Mammalian / cytology*
  • Embryo, Mammalian / drug effects*
  • Embryo, Mammalian / physiology
  • Estrogens, Non-Steroidal / blood*
  • Estrogens, Non-Steroidal / pharmacology*
  • Female
  • Fertilization in Vitro*
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Phenols / blood*
  • Phenols / pharmacology*


  • Benzhydryl Compounds
  • Estrogens, Non-Steroidal
  • Phenols
  • bisphenol A