[Expression of glycoprotein non-metastatic melanoma protein B in prostate cancer and its significance]

Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):496-9.
[Article in Chinese]

Abstract

Objective: To investigate the expression of glycoprotein non-metastatic melanoma protein B (GPNMB) in prostate cancer and its clinical significance.

Methods: The expression of GPNMB was analysed in 63 prostate cancer and 3 heterosexual hyperplasia prostate tissue and 8 benign prostatic hyperplasia samples by immunohistochemical staining, with integral optical density(IOD) value representing expression level of positive cells.

Results: The expression of GPNMB was lower in benign prostatic hyperplasia (BPH, IOD=70 017.49) than in Atypical hyperplasia (IOD=101 547.33, P=0.000 1) . The expression of GPNMB in tumor (IOD= 162 027.54) was higher than in non-tumor group (IOD=79 290.97), which included BPH and atypical hyperplasia (P=0.000 1). But GPNMB expression level was not positively elevated with degree of malignancy of prostate cancer. However, the expression of GPNMB in low pathological grading(IOD=177 944.30) was higher than that in high pathological grading(IOD=150 885.81, P=0.013).

Conclusion: The abnormal expression of GPNMB may play an important role in the development of prostate cancer and its detection may be useful for the early diagnosis of prostate cancer.

Publication types

  • English Abstract

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Humans
  • Male
  • Membrane Glycoproteins / metabolism*
  • Prostate / metabolism
  • Prostate / pathology
  • Prostatic Hyperplasia / metabolism
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology

Substances

  • Biomarkers, Tumor
  • GPNMB protein, human
  • Membrane Glycoproteins