Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1

Br J Nutr. 2012 Feb;107(4):567-72. doi: 10.1017/S0007114511003199. Epub 2011 Aug 16.


Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arachidonic Acid / blood
  • Asian
  • Asian People
  • Body Mass Index
  • Cohort Studies
  • Coronary Disease / blood
  • Coronary Disease / epidemiology*
  • Coronary Disease / ethnology
  • Cross-Sectional Studies
  • Fatty Acids, Omega-6 / administration & dosage
  • Fatty Acids, Omega-6 / blood*
  • Hawaii / epidemiology
  • Humans
  • Japan / epidemiology
  • Japan / ethnology
  • Linoleic Acid / blood
  • Male
  • Middle Aged
  • Models, Biological
  • Pennsylvania / epidemiology
  • Plasminogen Activator Inhibitor 1 / blood*
  • Risk Factors
  • White People


  • Fatty Acids, Omega-6
  • Plasminogen Activator Inhibitor 1
  • SERPINE1 protein, human
  • Arachidonic Acid
  • Linoleic Acid