Flow-dependent vasodilation of brachial artery in essential hypertension

Am J Physiol. 1990 Apr;258(4 Pt 2):H1004-11. doi: 10.1152/ajpheart.1990.258.4.H1004.


Brachial artery hemodynamics including brachial artery diameter (D) and local blood flow velocity (V) was studied in 15 normotensive subjects (NT) and 19 age-matched hypertensive patients (HT) at rest using a bidimensional pulsed Doppler system during a 2-min period of distal circulatory occlusion and during reactive hyperemia. Kinetics of changes in V and D were determined during successive and reproducible maneuvers. V and D decreased significantly during distal circulatory occlusion in both groups. During reactive hyperemia, V reached similar maximum values in both groups, and D increased significantly in NT and HT. Changes in D during reactive hyperemia were positively and significantly correlated with changes in V recorded at the same level. No significant difference was found between the two groups. These results demonstrate noninvasively that there are velocity-dependent variations in the diameter of a large artery in humans and suggest that velocity-dependent vasodilation of the brachial artery is not impaired in essential hypertension.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Flow Velocity
  • Blood Volume
  • Brachial Artery / physiopathology*
  • Female
  • Hemodynamics
  • Humans
  • Hypertension / physiopathology*
  • Male
  • Middle Aged
  • Reference Values
  • Regional Blood Flow
  • Ultrasonography
  • Vasodilation / physiology*