Hot-topic debate on hepatitis C virus: the type of immunosuppression matters

Liver Transpl. 2011 Nov;17 Suppl 3:S20-3. doi: 10.1002/lt.22414.

Abstract

1. The treatment of rejection is an important factor associated with the severe recurrence of hepatitis C virus (HCV) after liver transplantation. 2. The effects of calcineurin inhibitors, corticosteroids, and mycophenolate mofetil on HCV recurrence are equivocal. 3. Cyclosporine is associated with a higher sustained virological response in patients treated for HCV. 4. Because insulin resistance and diabetes are associated with fibrosis in HCV-infected liver transplant recipients, the use of immunosuppressive agents without this side effect may slow the posttransplant disease progression.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Calcineurin Inhibitors
  • Cyclosporine / therapeutic use
  • Graft Rejection / drug therapy*
  • Graft Rejection / epidemiology
  • Graft Rejection / immunology
  • Hepatitis C, Chronic / epidemiology
  • Hepatitis C, Chronic / immunology*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Liver Transplantation / immunology*
  • Mycophenolic Acid / analogs & derivatives
  • Mycophenolic Acid / therapeutic use
  • Recurrence
  • Risk Factors
  • Sirolimus / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Calcineurin Inhibitors
  • Immunosuppressive Agents
  • Cyclosporine
  • Mycophenolic Acid
  • Sirolimus