Insulin-like growth factor I - a novel biomarker of abdominal aortic aneurysms

Eur J Vasc Endovasc Surg. 2011 Nov;42(5):560-2. doi: 10.1016/j.ejvs.2011.07.013. Epub 2011 Aug 17.

Abstract

Objective: The study aimed to test the potential role of insulin-like growth factor I (IGF-I) and IGF-II as biomarkers for abdominal aortic aneurysm (AAA).

Methods and results: IGF-I and II levels were analysed in 115 patients with screening diagnosed AAA kept under annual surveillance for 10 years. Serum IGF-I correlated positively with AAA size and growth rate (r = 0.23, P = 0.016 and r = 0.27, P = 0.004), persisting after adjustment for potential confounders. Serum IGF-I level predicted cases needing later surgery (AOC: 0.63; 95% confidence interval: 0.52-0.73).

Conclusions: In this prospective, long-term study, baseline serum IGF-I correlated positively with AAA size and growth rate and predicted future need for preventive surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aortic Aneurysm, Abdominal / blood*
  • Aortic Aneurysm, Abdominal / diagnosis*
  • Aortic Aneurysm, Abdominal / therapy
  • Biomarkers / blood
  • Cohort Studies
  • Humans
  • Insulin-Like Growth Factor I / metabolism*
  • Insulin-Like Growth Factor II / metabolism*
  • Population Surveillance*
  • Predictive Value of Tests

Substances

  • Biomarkers
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II