[Pharmacological treatment for retinopathy of prematurity]

Ophthalmologe. 2011 Aug;108(8):777-85; quiz 786-7. doi: 10.1007/s00347-011-2371-4.
[Article in German]


Mandatory screening performed by an experience ophthalmologist remains the most important pillar in the management of retinopathy of prematurity (ROP). The current gold standard for treatment of proliferative ROP is still panretinal laser photocoagulation, depending on severity, in combination with vitreoretinal surgery if necessary. The first case series of off-label intravitreal anti-VEGF treatment are encouraging. In addition to intravitreal anti-VEGF therapy, other treatment concepts such as supplementation with IGF-1 or omega-3 fatty acids also represent interesting pharmacological approaches to the management of ROP. However, larger controlled trials are required to validate the benefits and safety of these systemic treatment approaches.

Publication types

  • English Abstract

MeSH terms

  • Angiogenesis Inhibitors / adverse effects
  • Angiogenesis Inhibitors / therapeutic use*
  • Antibodies, Monoclonal, Humanized / adverse effects
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Bevacizumab
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / drug therapy
  • Combined Modality Therapy
  • Fatty Acids, Omega-3 / therapeutic use*
  • Humans
  • Infant, Newborn
  • Insulin-Like Growth Factor I / therapeutic use*
  • Intravitreal Injections
  • Laser Coagulation
  • Mass Screening
  • Off-Label Use
  • Retinopathy of Prematurity / diagnosis
  • Retinopathy of Prematurity / drug therapy*
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors*
  • Vitrectomy


  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Fatty Acids, Omega-3
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Bevacizumab
  • Insulin-Like Growth Factor I