Notch signaling and Notch signaling modifiers

Int J Biochem Cell Biol. 2011 Nov;43(11):1550-62. doi: 10.1016/j.biocel.2011.08.005. Epub 2011 Aug 12.


Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of non-canonical extracellular factors has also been shown to modulate Notch signaling, conferring newly appreciated complexity to this evolutionarily conserved signal transduction system. Here, I review current concepts in Notch signaling, with a focus on work from the last decade elucidating novel extracellular proteins that up- or down-regulate signal potency.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology
  • Endocytosis / physiology
  • Gene Regulatory Networks / physiology
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Ligands
  • Neurons / cytology
  • Neurons / metabolism*
  • Protein Structure, Tertiary
  • Receptors, Notch / chemistry
  • Receptors, Notch / genetics
  • Receptors, Notch / metabolism*
  • Signal Transduction / physiology*


  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Receptors, Notch