Fatal diffuse alveolar damage associated with oxaliplatin administration

Clin Colorectal Cancer. 2011 Sep;10(3):198-202. doi: 10.1016/j.clcc.2011.03.019. Epub 2011 Apr 28.


Oxaliplatin-based chemotherapy regimens are currently a standard of care for the treatment of colorectal cancer in both the adjuvant and metastatic disease settings. Significant improvements in survival have resulted from the use of oxaliplatin-based combinations. This article describes the use of oxaliplatin-based chemotherapy in a patient with stage III colon cancer who developed fatal diffuse alveolar damage during his adjuvant therapy. Other cases of pulmonary toxicity associated with oxaliplatin use are presented and the proposed pathophysiology of this rare occurrence is discussed.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Lung Injury / chemically induced*
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Colonic Neoplasms / drug therapy*
  • Fatal Outcome
  • Fluorouracil / adverse effects
  • Humans
  • Leucovorin / adverse effects
  • Male
  • Organoplatinum Compounds / adverse effects
  • Pulmonary Alveoli / drug effects*
  • Pulmonary Alveoli / pathology*
  • Respiratory Insufficiency / chemically induced*


  • Organoplatinum Compounds
  • Leucovorin
  • Fluorouracil

Supplementary concepts

  • Folfox protocol