The expression of transcription factor 7-like 2 (TCF7L2) in fat and placental tissue from women with gestational diabetes

Mariusz Kuzmicki; Beata Telejko; Natalia Wawrusiewicz-Kurylonek; Katarzyna Kalejta; Adam Lemancewicz; Michal Zdrodowski; Marek Grabiec; Anna M Pryszczepko-Wawreszuk; Adam Kretowski; Maria Gorska; Jacek Szamatowicz

doi:10.1016/j.diabres.2011.07.033

The expression of transcription factor 7-like 2 (TCF7L2) in fat and placental tissue from women with gestational diabetes

Diabetes Res Clin Pract. 2011 Nov;94(2):e43-6. doi: 10.1016/j.diabres.2011.07.033. Epub 2011 Aug 19.

Authors

Mariusz Kuzmicki¹, Beata Telejko, Natalia Wawrusiewicz-Kurylonek, Katarzyna Kalejta, Adam Lemancewicz, Michal Zdrodowski, Marek Grabiec, Anna M Pryszczepko-Wawreszuk, Adam Kretowski, Maria Gorska, Jacek Szamatowicz

Affiliation

¹ Department of Gynecology, Medical University of Bialystok, Białystok, Poland. mkuzmicki@op.pl

PMID: 21855162
DOI: 10.1016/j.diabres.2011.07.033

Abstract

In the present study we showed that the expression of transcription factor 7-like 2 (TCF7L2) mRNA in visceral adipose tissue obtained from 20 women with gestational diabetes was lower than in 18 pregnant women with normal glucose tolerance (p = 0.02), however after adjusting for BMI values, the difference was not significant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biomarkers / blood
Blood Glucose / analysis
Body Mass Index
Case-Control Studies
Diabetes, Gestational / blood
Diabetes, Gestational / genetics*
Female
Glycated Hemoglobin / analysis
Humans
Intra-Abdominal Fat / chemistry*
Least-Squares Analysis
Placenta / chemistry*
Poland
Pregnancy
RNA, Messenger / analysis
Subcutaneous Fat / chemistry*
Transcription Factor 7-Like 2 Protein / genetics*

Substances

Biomarkers
Blood Glucose
Glycated Hemoglobin A
RNA, Messenger
TCF7L2 protein, human
Transcription Factor 7-Like 2 Protein
hemoglobin A1c protein, human