Colorectal cancers choosing sides

Biochim Biophys Acta. 2011 Dec;1816(2):219-31. doi: 10.1016/j.bbcan.2011.07.005. Epub 2011 Aug 10.


In contrast to the majority of sporadic colorectal cancer which predominantly occur in the distal colon, most mismatch repair deficient tumours arise at the proximal side. At present, these regional preferences have not been explained properly. Recently, we have screened colorectal tumours for mutations in Wnt-related genes focusing specifically on colorectal location. Combining this analysis with published data, we propose a mechanism underlying the side-related preferences of colorectal cancers, based on the specific acquired genetic defects in β-catenin signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain Neoplasms
  • Colorectal Neoplasms / genetics*
  • Genes, APC
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Neoplastic Syndromes, Hereditary
  • Organ Specificity
  • Wnt Signaling Pathway
  • beta Catenin / genetics
  • beta Catenin / physiology


  • beta Catenin

Supplementary concepts

  • Turcot syndrome