Cardiovascular disease in asthma and COPD: a population-based retrospective cross-sectional study

Respir Med. 2012 Feb;106(2):249-56. doi: 10.1016/j.rmed.2011.07.021.


We conducted a large population-based retrospective cross-sectional study for determining the extent of clinically recognized chronic obstructive pulmonary disease (COPD) and asthma, and the prevalence of associated cardiovascular diseases (CVDs), using information obtained from the Health Search Database (HSD) owned by the Italian College of General Practitioners (SIMG). Our study provides further evidence that patients with the diagnosis of COPD are at increased association with the diagnosis of most CVDs. It also documents that age clusters between 35 and 54 years are those at highest association of simultaneous presence of the diagnosis of CVD and that of COPD, with a progressive significant reduction in older age clusters. Moreover, it shows that the diagnosis of asthma is modestly associated with the diagnosis of different CV morbidities.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asthma / diagnosis
  • Asthma / epidemiology*
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / epidemiology*
  • Cross-Sectional Studies
  • Databases, Factual
  • Female
  • Humans
  • Italy / epidemiology
  • Male
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Pulmonary Disease, Chronic Obstructive / diagnosis
  • Pulmonary Disease, Chronic Obstructive / epidemiology*
  • Retrospective Studies
  • Smoking / adverse effects
  • Smoking / epidemiology*