Neuroprotective cadinane sesquiterpenes from the resinous exudates of Commiphora myrrha

Fitoterapia. 2011 Dec;82(8):1198-201. doi: 10.1016/j.fitote.2011.08.001. Epub 2011 Aug 11.

Abstract

Three new cadinane sesquiterpenes, commiterpenes A-C, were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). All the isolated sesquiterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.

MeSH terms

  • Cell Death / drug effects
  • Cell Line
  • Commiphora / chemistry*
  • Humans
  • Molecular Structure
  • Neurons / drug effects*
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / pharmacology*
  • Plant Extracts / pharmacology*
  • Plant Exudates / chemistry
  • Plant Exudates / pharmacology
  • Resins, Plant
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*

Substances

  • Neuroprotective Agents
  • Plant Extracts
  • Plant Exudates
  • Resins, Plant
  • Sesquiterpenes
  • commiterpene A
  • commiterpene B
  • commiterpene C