Neuroprotective cadinane sesquiterpenes from the resinous exudates of Commiphora myrrha

Abstract

Three new cadinane sesquiterpenes, commiterpenes A-C, were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). All the isolated sesquiterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.