Thyroid autoantibodies and pregnancy outcomes

Clin Obstet Gynecol. 2011 Sep;54(3):499-505. doi: 10.1097/GRF.0b013e31822730b9.


Autoimmune thyroid disease has been associated with several adverse pregnancy outcomes. Increased risk of spontaneous miscarriage and placental abruption in women with thyroid antibodies has been confirmed in multiple studies. However, benefit of intervention and treatment of autoimmune thyroid disease in otherwise euthyroid pregnant women has not been sufficiently studied. The data on the association of thyroid antibodies and recurrent pregnancy loss or preterm birth are conflicting and a statistically significant association has not been shown in large studies. At present time, routine screening and treatment of autoimmune thyroid disease in euthyroid pregnant women is not warranted.

Publication types

  • Review

MeSH terms

  • Autoantibodies / blood*
  • Autoimmune Diseases / immunology*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications*
  • Pregnancy Outcome*
  • Thyroid Diseases / immunology*


  • Autoantibodies