Game changers: why did the scale-up of HIV treatment work despite weak health systems?

J Acquir Immune Defic Syndr. 2011 Aug:57 Suppl 2:S61-3. doi: 10.1097/QAI.0b013e3182217f00.


Game changers are radical innovations that result in fundamental and durable changes. The global HIV program scale-up witnessed over the past decade has included some innovations that are not well appreciated. The willingness to rapidly adopt and implement innovations, the flexibility and speed of program implementation, and the readiness to re-examine professional roles are just a few of such game changers. However, moving ahead, further work is needed to enhance the quality of programs, to energetically tackle HIV prevention, to build on this success, and to address other health threats that these same communities face.

MeSH terms

  • Anti-HIV Agents / economics
  • Anti-HIV Agents / therapeutic use
  • Delivery of Health Care / economics*
  • Delivery of Health Care / statistics & numerical data
  • Developing Countries / economics
  • Developing Countries / statistics & numerical data
  • Financing, Government / economics
  • Financing, Government / statistics & numerical data
  • HIV Infections / drug therapy
  • HIV Infections / economics*
  • HIV Infections / epidemiology
  • HIV Infections / transmission
  • Health Services Needs and Demand / economics
  • Health Services Needs and Demand / statistics & numerical data
  • Humans
  • International Cooperation
  • Public Health / economics
  • Public Health / statistics & numerical data


  • Anti-HIV Agents