Local and intralesional therapy of in-transit melanoma metastases

J Surg Oncol. 2011 Sep;104(4):391-6. doi: 10.1002/jso.22029.


Regional relapse of melanoma may occur as satellite or in-transit metastases proximal to the primary tumor in the direction of the lymph flow. The management of in-transit metastases is challenging because the efficacy of treatment is largely dictated by the biological behavior of the patient's melanoma. This review examines local treatment modalities.

Publication types

  • Review

MeSH terms

  • Administration, Topical
  • Antineoplastic Agents / administration & dosage*
  • Cytokines / administration & dosage
  • Electrochemotherapy
  • Humans
  • Immunotherapy
  • Injections, Intralesional
  • Lymphatic Metastasis
  • Melanoma / secondary
  • Melanoma / therapy*
  • Mycobacterium bovis
  • Radiotherapy
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*


  • Antineoplastic Agents
  • Cytokines