Kinetic resolution of β-lactams via enantioselective N-acylation

Org Lett. 2011 Sep 16;13(18):4755-7. doi: 10.1021/ol201911z. Epub 2011 Aug 22.

Abstract

Enantioselective N-acylation of 4-aryl-β-lactams in the presence of acyl transfer catalyst Cl-PIQ provides an effective method for their non-enzymatic kinetic resolution.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acylation
  • Catalysis
  • Kinetics
  • Molecular Structure
  • Stereoisomerism
  • beta-Lactams / chemistry*

Substances

  • beta-Lactams