Appendiceal Adenocarcinoids With Peritoneal Carcinomatosis Treated With Cytoreductive Surgery and Intraperitoneal Chemotherapy: A Retrospective Study of in Vitro Drug Sensitivity and Survival

Clin Colorectal Cancer. 2011 Jun;10(2):108-12. doi: 10.1016/j.clcc.2011.03.006. Epub 2011 Apr 22.

Abstract

Purpose: The purpose of this study was to present results on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) of appendiceal adenocarcinoid (AAC) with peritoneal carcinomatosis (PC), to assess drug sensitivity of AAC, as compared with colorectal cancer (CRC), and to report any discordant histopathology.

Methods: Ten patients were treated with CRS and HIPEC. Treatment, drug sensitivity profiles, histopathology, and survival data were recorded and matched with potential prognostic indicators. Drug sensitivity was assessed with short-term fluorometric microculture cytotoxicity assay and compared with peritoneal metastases from CRC.

Results: Patients with completeness of cytoreduction score (CC) ≤ 1 had better median survival (36.6 months) than those with CC > 1 (16.4 months). In the CC ≤ 1 group, 8 months elapsed between initial diagnosis and CRS with HIPEC compared with 22 months in the CC > 1 group. For standard drugs, tumor cells from AAC and CRC were equally sensitive; except for docetaxel, to which AAC was more sensitive than CRC.

Conclusion: The CC-score correlated with overall survival. Candidates for this type of treatment should be referred early for evaluation in order to reach a better CC score. Drugs used for CRC also seem adequate for treatment of AAC, although other drugs, eg, docetaxel, might be more active.

MeSH terms

  • Adenocarcinoma / secondary
  • Adenocarcinoma / therapy*
  • Adult
  • Aged
  • Antineoplastic Agents / administration & dosage*
  • Appendiceal Neoplasms / pathology
  • Appendiceal Neoplasms / therapy*
  • Chemotherapy, Cancer, Regional Perfusion
  • Digestive System Surgical Procedures
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • Hyperthermia, Induced
  • Male
  • Middle Aged
  • Peritoneal Neoplasms / pathology
  • Peritoneal Neoplasms / therapy*
  • Retrospective Studies
  • Young Adult

Substances

  • Antineoplastic Agents

Supplementary concepts

  • Adenocarcinoid tumor