Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections

J Innate Immun. 2012;4(2):213-8. doi: 10.1159/000329550. Epub 2011 Aug 19.

Abstract

Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blotting, Western
  • Hypoxia-Inducible Factor 1, alpha Subunit / immunology
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nitric Oxide / biosynthesis
  • Nitric Oxide / immunology
  • Streptococcal Infections / immunology*
  • Streptococcal Infections / metabolism
  • Streptococcus pyogenes / immunology
  • Toll-Like Receptor 9 / immunology*
  • Toll-Like Receptor 9 / metabolism

Substances

  • Hif1a protein, mouse
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Toll-Like Receptor 9
  • Nitric Oxide