Hospital course and short-term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis

Pediatr Infect Dis J. 2012 Jan;31(1):89-90. doi: 10.1097/INF.0b013e31822fb15d.


Our objective was to characterize the hospital course and short-term outcomes of neonates exposed to prolonged rupture of membranes (PROM), chorioamnionitis (CH), or both PROM and CH. Outcomes were positive blood culture and/or clinical signs of infection (+BC/CSI) prompting >4 days of antibiotics. Six neonates had a positive BC, 2 (0.6%) in the CH group and 4 (2.7%) in the PROM + CH group (P = 0.05); none of the neonates exposed to PROM alone had a +BC. These results support our current approach of withholding routine antibiotic therapy in neonates exposed to PROM alone.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Blood / microbiology
  • Chorioamnionitis / drug therapy*
  • Culture Media
  • Female
  • Fetal Membranes, Premature Rupture / drug therapy*
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / drug therapy*
  • Length of Stay
  • Perinatal Care / methods*
  • Pregnancy
  • Pregnancy Complications, Infectious
  • Risk Factors
  • Sepsis / prevention & control*


  • Anti-Bacterial Agents
  • Culture Media