The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

Nat Rev Mol Cell Biol. 2011 Aug 23;12(9):605-20. doi: 10.1038/nrm3173.


Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular processes in eukaryotes through highly specific modification of numerous cellular proteins, which is often tightly regulated in a spatial and temporal manner. Although most often associated with proteasomal degradation, ubiquitylation frequently serves non-proteolytic functions. In light of its central roles in cellular regulation, it has not been surprising to find that many of the components of the ubiquitin system itself are regulated by ubiquitylation. This observation has broad implications for pathophysiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Food Chain
  • Humans
  • Models, Biological
  • Proteasome Endopeptidase Complex / metabolism*
  • Proteasome Endopeptidase Complex / physiology
  • Protein Processing, Post-Translational / physiology*
  • Ubiquitin / metabolism*
  • Ubiquitination / physiology*
  • Wit and Humor as Topic


  • Ubiquitin
  • Proteasome Endopeptidase Complex