Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old

J Korean Med Sci. 2011 Aug;26(8):1093-8. doi: 10.3346/jkms.2011.26.8.1093. Epub 2011 Jul 27.


There are inconsistent findings on the effects of vitamin K on bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC). The present intervention study evaluated the effect in subjects over 60-yr-old. The vitamin K group (vitamin K + vitamin D + calcium supplement; 15 mg of vitamin K2 [menatetrenone] three times daily, 400 IU of vitamin D once a day, and 315 mg of calcium twice daily) and the control group (vitamin D + calcium supplement) were randomly assigned. During the six months of treatment, seventy eight women participated (38 in the vitamin K group and 40 in the control group) and 45 women completed the study. The baseline characteristics of study participants did not differ between the vitamin K and the control groups. In a per protocol analysis after 6 months, L3 bone mineral density has increased statistically significantly in the vitamin K group compared to the control group (0.01 ± 0.03 g/cm(2) vs -0.008 ± 0.04 g/cm(2), P = 0.049). UcOC concentration was also significantly decreased in the vitamin K group (-1.6 ± 1.6 ng/dL vs -0.4 ± 1.1 ng/dL, P = 0.008). In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration.

Keywords: Bone Mineral Density; Korean Women; Undercarboxylated osteocalcin; Vitamin K.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Bone Density / drug effects*
  • Calcium / administration & dosage*
  • Dietary Supplements
  • Female
  • Humans
  • Middle Aged
  • Osteocalcin / blood*
  • Postmenopause
  • Republic of Korea
  • Vitamin D / administration & dosage*
  • Vitamin K / administration & dosage*


  • Osteocalcin
  • Vitamin K
  • Vitamin D
  • Calcium