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. 2011 Jul 15;2(7):108-13.
doi: 10.4239/wjd.v2.i7.108.

Diabetes and cancer: Looking at the multiligand/RAGE axis

Armando Rojas  1 , Ileana González, Erik Morales, Ramón Pérez-Castro, Jacqueline Romero, Héctor Figueroa
Affiliations

Diabetes and cancer: Looking at the multiligand/RAGE axis

Armando Rojas et al. World J Diabetes. .

Abstract

The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many years. Although the association is not fully understood, current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms, including hyperinsulinemia, hyperglycemia and chronic inflammation. In this context, the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor growth. We highlight how RAGE, once activated, as it manifests itself in conditions such as diabetes or hyperglycemia, is able to continuously bring about an inflammatory milieu, thus supporting the contribution of chronic inflammation to the development of malignancies.

Keywords: Cancer; Diabetes; Inflammation; Malignant transformation; Receptor for advanced glycation end-products.

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Figures

Figure 1
Figure 1
RAGE engagement activates many signaling pathways which are involved in both diabetes-associated vascular complications and tissue damage, and as well as in the tumor microenvironment-associated inflammatory milieu. RAGE: Receptor of advanced glycation end-products.
Figure 2
Figure 2
Schematic depiction of consequences of RAGE activation in both diabetes and cancer. A common focal point is the onset and perpetuation of inflammatory conditions.
See this image and copyright information in PMC

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