Abstract
The stereoselective synthesis of truncated 3'-aminocarbanucleosides 4a-d via a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A(3) adenosine receptor are described.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry*
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Humans
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Molecular Structure
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Nucleosides / chemistry*
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Nucleosides / metabolism
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Protein Binding
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Receptor, Adenosine A3 / chemistry*
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Receptor, Adenosine A3 / metabolism
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Stereoisomerism
Substances
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Amines
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Nucleosides
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Receptor, Adenosine A3