Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor

Org Biomol Chem. 2011 Oct 21;9(20):6955-62. doi: 10.1039/c1ob05853c. Epub 2011 Aug 23.

Abstract

The stereoselective synthesis of truncated 3'-aminocarbanucleosides 4a-d via a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A(3) adenosine receptor are described.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Humans
  • Molecular Structure
  • Nucleosides / chemistry*
  • Nucleosides / metabolism
  • Protein Binding
  • Receptor, Adenosine A3 / chemistry*
  • Receptor, Adenosine A3 / metabolism
  • Stereoisomerism

Substances

  • Amines
  • Nucleosides
  • Receptor, Adenosine A3