Most recent developments and modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan derivatives

Mini Rev Med Chem. 2011 Oct;11(12):1002-8. doi: 10.2174/138955711797247752.


The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Morphinans / chemical synthesis
  • Morphinans / chemistry
  • Morphinans / pharmacology*
  • Narcotic Antagonists*
  • Pain / drug therapy*
  • Receptors, Opioid / agonists*
  • Structure-Activity Relationship


  • 4,5-epoxymorphinan
  • Morphinans
  • Narcotic Antagonists
  • Receptors, Opioid