Abstract
The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Humans
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Morphinans / chemical synthesis
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Morphinans / chemistry
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Morphinans / pharmacology*
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Narcotic Antagonists*
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Pain / drug therapy*
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Receptors, Opioid / agonists*
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Structure-Activity Relationship
Substances
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4,5-epoxymorphinan
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Morphinans
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Narcotic Antagonists
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Receptors, Opioid