Increase of success rate for women undergoing embryo transfer by transcutaneous electrical acupoint stimulation: a prospective randomized placebo-controlled study

Fertil Steril. 2011 Oct;96(4):912-6. doi: 10.1016/j.fertnstert.2011.07.1093. Epub 2011 Sep 8.


Objective: To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on pregnancy rates (PR) in women undergoing ET.

Design: Prospective, randomized, single-blinded placebo-controlled clinical trial.

Setting: Research and laboratory facilities.

Patient(s): A total of 309 patients, less than 45 years old, undergoing cryopreservation embryos transplant or fresh cycle IVF with or without intracytoplasmic sperm injection (ICSI).

Intervention(s): The subjects were randomly allocated to three groups: mock TEAS treatment: 30 minutes after ET (group I, n = 99); single TEAS treatment: 30 minutes after ET (group II, n = 110); and double TEAS treatments: 24 hours before ET and 30 minutes after ET (group III, n = 100).

Main outcome measure(s): Clinical PR, embryos implantation rate, live birth rate.

Result(s): The clinical PR, embryos implantation rate, and live birth rate of group I (29.3%, 15.0%, and 21.2%, respectively) were significantly lower than those in group II (42.7%, 25.7%, and 37.3%, respectively) and group III (50.0%, 25.9%, and 42.0%, respectively).

Conclusion(s): Transcutaneous electrical acupoint stimulation, especially double TEAS, significantly improved the clinical outcome of ET.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acupuncture Points*
  • Adult
  • Embryo Transfer / instrumentation
  • Embryo Transfer / methods*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Rate / trends*
  • Prospective Studies
  • Single-Blind Method
  • Transcutaneous Electric Nerve Stimulation / instrumentation
  • Transcutaneous Electric Nerve Stimulation / methods*
  • Treatment Outcome