Fatigue among stroke patients on long-term follow-up. The Bergen Stroke Study

J Neurol Sci. 2012 Jan 15;312(1-2):138-41. doi: 10.1016/j.jns.2011.08.002. Epub 2011 Aug 20.


Background: To evaluate characteristics and mortality related to post-stroke fatigue (PSF).

Methods: All surviving stroke patients admitted to the Stroke Unit, Haukeland University Hospital, between February 2006 and November 2008 were sent a postal questionnaire including the Fatigue Severity Scale (FSS), the hospital anxiety and depression scale (HADSD), and the Barthel Index (BI) at least 6 months after stroke onset. Survival among patients returning the questionnaire was determined by November 2009. PSF was defined as FSS score ≥5.

Results: Among 377 patients returning the questionnaire, 42.3% had PSF. Logistic regression showed that PSF was independently associated with pre-stroke depression, leucoaraiosis, myocardial infarction, diabetes mellitus, pain, and sleeping disturbances. Mean FSS score was lower among TIA patients than among patients with minor cerebral infarction (patients with BI=100) (P=.002). Cox regression analysis showed mortality to be associated with PSF.

Conclusion: There is a multifactorial basis for PSF suggesting different therapy options. Cerebral lesions may cause PSF in some patients. Post-stroke fatigue is associated with higher mortality.

MeSH terms

  • Aged
  • Anxiety / mortality
  • Cerebral Hemorrhage / mortality
  • Cerebral Hemorrhage / psychology
  • Cerebral Infarction / mortality
  • Cerebral Infarction / psychology
  • Comorbidity
  • Depression / mortality
  • Fatigue / mortality*
  • Fatigue / psychology
  • Female
  • Follow-Up Studies
  • Humans
  • Ischemic Attack, Transient / mortality
  • Ischemic Attack, Transient / psychology
  • Male
  • Prognosis
  • Severity of Illness Index*
  • Stroke / mortality*
  • Stroke / psychology
  • Surveys and Questionnaires / standards
  • Time Factors