Strategies for extended serum half-life of protein therapeutics

Curr Opin Biotechnol. 2011 Dec;22(6):868-76. doi: 10.1016/j.copbio.2011.06.012. Epub 2011 Aug 20.


With a growing number of protein therapeutics being developed, many of them exhibiting a short plasma half-life, half-life extension strategies find increasing attention by the biotech and pharmaceutical industry. Extension of the half-life can help to reduce the number of applications and to lower doses, thus are beneficial for therapeutic but also economic reasons. Here, a comprehensive overview of currently developed half-life extension strategies is provided including those aiming at increasing the hydrodynamic volume of a protein drug but also those implementing recycling processes mediated by the neonatal Fc receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carbohydrate Metabolism
  • Glycosylation
  • Half-Life
  • Humans
  • Hydrodynamics
  • Polyethylene Glycols / metabolism
  • Protein Engineering
  • Proteins / metabolism
  • Proteins / therapeutic use
  • Recombinant Proteins / metabolism*
  • Recombinant Proteins / therapeutic use
  • Serum / metabolism*


  • Proteins
  • Recombinant Proteins
  • Polyethylene Glycols