Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention

Clin Transl Oncol. 2011 Sep;13(9):599-610. doi: 10.1007/s12094-011-0705-y.


Gastric cancer is the major cause of cancer-related deaths worldwide. The majority of them are classified as sporadic, whereas the remaining 10% exhibit familial clustering. Hereditary diffuse gastric cancer (HDGC) syndrome is the most important condition that leads to hereditary gastric cancer. However, other hereditary cancer syndromes, such as hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, Peutz-Jeghers syndrome, Li-Fraumeni syndrome and hereditary breast and ovarian cancer, entail a higher risk compared to the general population for developing this kind of neoplasia. In this review, we describe briefly the most important aspects related to clinical features, molecular biology and strategies for prevention in hereditary gastric associated to different cancer syndromes.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyposis Coli / genetics
  • Adenomatous Polyposis Coli / pathology
  • Adenomatous Polyposis Coli / therapy
  • Carcinoma* / diagnosis
  • Carcinoma* / genetics
  • Carcinoma* / pathology
  • Carcinoma* / prevention & control
  • Genetic Counseling / methods
  • Genetic Predisposition to Disease
  • Humans
  • Models, Biological
  • Molecular Biology / methods
  • Neoplastic Syndromes, Hereditary* / diagnosis
  • Neoplastic Syndromes, Hereditary* / genetics
  • Neoplastic Syndromes, Hereditary* / pathology
  • Neoplastic Syndromes, Hereditary* / prevention & control
  • Preventive Medicine / methods*
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / genetics
  • Stomach Neoplasms* / pathology
  • Stomach Neoplasms* / prevention & control