Growth plate senescence and catch-up growth

Endocr Dev. 2011;21:23-29. doi: 10.1159/000328117. Epub 2011 Aug 22.

Abstract

Longitudinal bone growth is rapid in prenatal and early postnatal life, but then slows with age and eventually ceases. This growth deceleration is caused primarily by a decrease in chondrocyte proliferation, and is associated with other structural, functional, and molecular changes collectively termed growth plate senescence. Current evidence suggests that growth plate senescence occurs because the progenitor chondrocytes in the resting zone have a limited replicative capacity which is gradually exhausted with increasing cell division. In addition, recent experimental findings from laboratory and clinical studies suggest that growth plate senescence explains the phenomenon of catch-up growth. Growth-inhibiting conditions such as glucocorticoid excess and hypothyroidism delay the program of growth plate senescence. Consequently, growth plates are less senescent after these conditions resolve and therefore grow more rapidly than is normal for age, resulting in catch-up growth.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Bone Development / genetics
  • Bone Development / physiology
  • Cellular Senescence / genetics
  • Cellular Senescence / physiology*
  • Growth Plate / cytology
  • Growth Plate / growth & development*
  • Growth Plate / physiology*
  • Humans