Cancer mortality among aircraft manufacturing workers: an extended follow-up

J Occup Environ Med. 2011 Sep;53(9):992-1007. doi: 10.1097/JOM.0b013e31822e0940.


Objective: Extended cancer follow-up among 77,943 aircraft workers.

Methods: Comprehensive exposure information enabled detailed classification of trichloroethylene (TCE), perchloroethylene (PCE), mixed solvents, and chromates exposure among these workers.

Results: Exposure to TCE, PCE, mixed solvents or chromates was not associated with increased cancer risk overall or for most cancer sites. Elevated rates compared with the general population were seen for non-Hodgkin lymphoma for PCE exposure, and colon and testicular cancers and multiple myeloma for mixed solvents exposure. Internal cohort analyses, however, showed no significant trends of increasing risk for these cancers with increasing years of exposure to TCE, PCE or mixed solvents.

Conclusion: This large, long-term cohort study with comprehensive exposure assessment found no consistent evidence of increased cancer risk overall or by site among aircraft workers, including those with long-term exposure to TCE, PCE, and mixed solvents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aircraft / statistics & numerical data*
  • California / epidemiology
  • Chromates / adverse effects
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Neoplasms / chemically induced
  • Neoplasms / mortality*
  • Occupational Diseases / chemically induced
  • Occupational Diseases / mortality*
  • Occupational Exposure / adverse effects*
  • Solvents / adverse effects
  • Tetrachloroethylene / adverse effects
  • Trichloroethylene / adverse effects


  • Chromates
  • Solvents
  • Trichloroethylene
  • Tetrachloroethylene