Effect of calcium dobesilate on the blood-retinal barrier in early diabetic retinopathy

Int Ophthalmol. 1990 Mar;14(2):81-8. doi: 10.1007/BF00154206.


The effect of calcium dobesilate on the alteration of the blood-retinal barrier was studied in 41 adult-onset, non-insulin dependent diabetic patients with minimal or no retinopathy, randomly assigned to receive either oral calcium dobesilate (1000 mg twice daily) or a placebo for 12 months. The posterior vitreous value and the penetration ratio, determined by vitreous fluorophotometry, reflected stabilisation of blood-retinal barrier permeability in the calcium dobesilate patients and deterioration of blood retinal barrier in those given placebo. During the relatively short period of the study, one year, no significant change in microaneurysm and capillary closure gradings was observed. No side effects were associated with calcium dobesilate.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Analysis of Variance
  • Benzenesulfonates / pharmacology*
  • Blood-Retinal Barrier / drug effects*
  • Calcium Dobesilate / pharmacokinetics
  • Calcium Dobesilate / pharmacology*
  • Diabetic Retinopathy / drug therapy*
  • Diabetic Retinopathy / metabolism
  • Double-Blind Method
  • Female
  • Fluorophotometry
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Permeability
  • Randomized Controlled Trials as Topic
  • Vitreous Body / metabolism


  • Benzenesulfonates
  • Calcium Dobesilate