Importance of organisms producing broad-spectrum SHV-group beta-lactamases into the United Kingdom

J Antimicrob Chemother. 1990 Mar;25(3):343-51. doi: 10.1093/jac/25.3.343.


We report the isolation of three strains of Klebsiella pneumoniae sensu lato, brought into the United Kingdom by patients from Greece and Egypt, that showed plasmid-determined resistance to ceftazidime. All three produced beta-lactamases shown by DNA hybridisation studies to belong to the SHV group. One produced an enzyme that appeared to be related to, but distinguishable from, SHV-1; another SHV-2 and the third SHV-5.

MeSH terms

  • Blotting, Southern
  • Ceftazidime / pharmacology
  • DNA, Bacterial / genetics
  • Drug Resistance, Microbial
  • Isoelectric Focusing
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests
  • Nucleic Acid Hybridization
  • R Factors
  • United Kingdom
  • beta-Lactamases / biosynthesis*


  • DNA, Bacterial
  • Ceftazidime
  • beta-Lactamases