Glucosensing and glucose homeostasis: from fish to mammals

Comp Biochem Physiol B Biochem Mol Biol. 2011 Dec;160(4):123-49. doi: 10.1016/j.cbpb.2011.07.006. Epub 2011 Aug 17.


This review is focused on two topics related to glucose in vertebrates. In a first section devoted to glucose homeostasis we describe how glucose levels fluctuate and are regulated in different classes of vertebrates. The detection of these fluctuations is essential for homeostasis and for other physiological processes such as regulation of food intake. The capacity of that detection is known as glucosensing, and the different mechanisms through which it occurs are known as glucosensors. Different glucosensor mechanisms have been demonstrated in different tissues and organs of rodents and humans whereas the information obtained for other vertebrates is scarce. In the second section of the review we describe the present knowledge regarding glucosensor mechanisms in different groups of vertebrates, with special emphasis in fish.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Eating
  • Fishes
  • Glucokinase / metabolism*
  • Glucose / metabolism*
  • Glucose Intolerance
  • Glucose Transport Proteins, Facilitative / metabolism*
  • Homeostasis / physiology*
  • Humans
  • Insulin-Secreting Cells / metabolism*
  • Mammals
  • Species Specificity


  • Blood Glucose
  • Glucose Transport Proteins, Facilitative
  • Glucokinase
  • Glucose