Peptic ulcer disease

Prim Care. 2011 Sep;38(3):383-94, vii. doi: 10.1016/j.pop.2011.05.001.

Abstract

Peptic ulcer disease (PUD) is due mostly to the widespread use of low-dose aspirin and nonsteroidal anti-inflammator drugs. It occurs mostly in older patients and those with comorbidities. Pain awakening the patient from sleep between 12 and 3 a.m. affects two-thirds of duodenal ulcer patients and one-third of gastric ulcer patients. Older adults (>80 years old) with PUD often do not present with abdominal pain; instead, epigastric pain, nausea and vomiting are among their most common presenting symptoms.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Gastrointestinal Agents / therapeutic use*
  • Helicobacter Infections / complications
  • Humans
  • Peptic Ulcer / complications*
  • Peptic Ulcer / drug therapy*
  • Peptic Ulcer / etiology
  • Racial Groups
  • Risk Factors
  • United States / epidemiology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Gastrointestinal Agents