Oral misoprostol for the management of incomplete abortion in Ecuador

Int J Gynaecol Obstet. 2011 Nov;115(2):135-9. doi: 10.1016/j.ijgo.2011.06.015. Epub 2011 Aug 26.


Objective: To assess the feasibility of introducing misoprostol for the treatment of incomplete abortion in Quito, Ecuador.

Methods: In a randomized prospective study conducted at a large tertiary-level maternity hospital and a private secondary-level clinic between November 2006 and November 2007, women with incomplete abortion were treated with either 600 μg of oral misoprostol (n=122) or manual vacuum aspiration (MVA) (n=120). All participants were requested to return for follow-up care on day 7 to determine the success of the treatment and to document their satisfaction with the method and the adverse effects experienced.

Results: Sixteen percent of women (39/242) did not return for their follow-up visit and their outcomes are unknown. Among those who did return, 94% (100/106) of women showed successful completion of abortion after treatment with misoprostol, as compared with 100% (97/97) of women treated with MVA. Most women described their adverse effects after treatment as tolerable (misoprostol, 95%; MVA, 91%). Nearly all women reported being satisfied with their treatment (196/203); there were no differences among the women's reports of satisfaction according to treatment received.

Conclusion: An oral dose of 600 μg of misoprostol was found to be an acceptable and effective non-surgical option for treating incomplete abortion. Clinical trials.gov NCT00674232.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortifacient Agents, Nonsteroidal / administration & dosage
  • Abortifacient Agents, Nonsteroidal / therapeutic use*
  • Abortion, Incomplete / drug therapy*
  • Abortion, Incomplete / surgery
  • Administration, Oral
  • Adult
  • Ecuador
  • Female
  • Humans
  • Maternal Health Services
  • Misoprostol / administration & dosage
  • Misoprostol / therapeutic use*
  • Patient Satisfaction*
  • Pregnancy
  • Prospective Studies
  • Vacuum Curettage


  • Abortifacient Agents, Nonsteroidal
  • Misoprostol

Associated data

  • ClinicalTrials.gov/NCT00674232