Induction of fertile oestrus in the bitch using Deslorelin, a GnRH agonist

Theriogenology. 2011 Nov;76(8):1561-6. doi: 10.1016/j.theriogenology.2011.06.031. Epub 2011 Aug 26.


Oestrus induction in various canine breeds was attempted in 32 bitches. A group of 8 bitches were treated 80-160 d following their previous oestrus (G1) whereas a second group of 24 bitches (G2) were implanted 200-590 d following their previous oestrus. The treatment for each bitch consisted in one Deslorelin implant (Suprelorin® 4,7 mg, Virbac, France), inserted subcutaneously in the post-umbilical region. Ovulation, pregnancy rate and litter size were recorded. All bitches came in heat 4.3 ± 1.4 d after implantation (2-7 d). Ovulation was reported in 62.5% in G1 and 87.5% in G2. One bitch refused mating and since no AI was performed, she was not considered for further analysis. Pregnancy was obtained in 25% in G1 versus 78.3% in G2. Mean litter size was 6.7 ± 3.5 puppies (1-14). Luteal failure was suspected in 3 bitches, two that remained non-pregnant and one which aborted 58 d post-ovulation since the owner refused progesterone supplementation. Deslorelin implants can therefore be considered as a valuable alternative to induce fertile oestrus in bitches in anoestrus. Follow-up of the luteal phase is recommended, since some bitches might encounter luteal failure.

MeSH terms

  • Animals
  • Dogs
  • Enzyme Inhibitors / administration & dosage
  • Enzyme Inhibitors / pharmacology*
  • Estrus / drug effects*
  • Female
  • Gonadotropin-Releasing Hormone / agonists*
  • Ovulation / drug effects
  • Pregnancy
  • Prostheses and Implants
  • Triptorelin Pamoate / administration & dosage
  • Triptorelin Pamoate / analogs & derivatives*
  • Triptorelin Pamoate / pharmacology


  • Enzyme Inhibitors
  • Triptorelin Pamoate
  • Gonadotropin-Releasing Hormone
  • deslorelin