Neuroprotection in metabolism-based therapy

Epilepsy Res. 2012 Jul;100(3):286-94. doi: 10.1016/j.eplepsyres.2011.04.016. Epub 2011 Aug 26.


Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing. Data demonstrating the use of different forms of metabolism-based therapy in human trials of Alzheimer disease and Parkinson disease are discussed. Animal and in vitro studies have shed light on metabolism-based therapy's mechanisms in these diseases, as well as ALS, aging, ischemia, trauma and mitochondrial cytopathies. Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy).

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / diet therapy*
  • Animals
  • Caloric Restriction*
  • Diet, Ketogenic*
  • Humans
  • Neurodegenerative Diseases / diet therapy*
  • Neuroprotective Agents / therapeutic use
  • Parkinson Disease / diet therapy*


  • Neuroprotective Agents