Resistance training dose response in combined endurance-resistance training in patients with cardiovascular disease: a randomized trial

Arch Phys Med Rehabil. 2011 Oct;92(10):1527-33. doi: 10.1016/j.apmr.2011.04.021. Epub 2011 Aug 27.

Abstract

Objective: To compare the effectiveness of 2 different volumes of resistance training (RT) combined with aerobic training in residential cardiac rehabilitation (CR).

Design: Randomized prospective cohort study.

Setting: Center for inpatient CR.

Participants: Patients (N=295) with a mean age ± SD of 62.7±11.7 years participated in the study.

Interventions: Patients were randomly divided into 2 groups (group 1 and group 2) with different volumes of RT; 2 sets × 12 repetitions (REPS) (group 1) and 3 sets × 15 REPS (group 2) per session, 2 times per week; each RT session consisting of 10 different resistance exercises. In addition, patients also completed continuous moderate intensity aerobic training composed of cycle ergometry 6 times per week for 17±4 minutes (mean ± SD) and walking 5 times per week for 45 minutes.

Main outcome measures: At entry and after 26±4 (mean ± SD) days of CR, blood pressure, heart rate, maximal oxygen consumption, and maximal power determined during cycle ergometry, strength determined via RT, and blood biochemistries were assessed. Data were analyzed via a 2-way (group × time) repeated measures analysis of variance.

Results: Statistical analysis revealed equivalent improvements in exercise capacity, muscular strength, hemodynamics, and blood chemistries regardless of RT volume (comparison-wise type I error rate, α<.01).

Conclusions: Our results show that nearly doubling (3 sets × 15 REPS vs 2 sets × 12 REPS) the volume of RT as part of a residential CR program does not yield further improvement in strength and cardiovascular risk factors.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Analysis of Variance
  • Biomarkers / analysis
  • Cardiac Rehabilitation*
  • Cardiovascular Diseases / diagnostic imaging
  • Cardiovascular Diseases / physiopathology
  • Exercise Test
  • Female
  • Heart Rate / physiology
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength / physiology
  • Oxygen Consumption / physiology
  • Physical Endurance / physiology
  • Prospective Studies
  • Resistance Training / methods*
  • Treatment Outcome
  • Ultrasonography

Substances

  • Biomarkers