Review
doi: 10.1016/0968-0004(90)90213-u.
Prenyl proteins in eukaryotic cells: a new type of membrane anchor
Affiliations
- PMID: 2187294
- DOI: 10.1016/0968-0004(90)90213-u
Item in Clipboard
Review
Prenyl proteins in eukaryotic cells: a new type of membrane anchor
Trends Biochem Sci.
1990 Apr.
Abstract
Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.
Similar articles
-
Posttranslational modification of proteins by isoprenoids in mammalian cells.FASEB J. 1990 Dec;4(15):3319-28. doi: 10.1096/fasebj.4.15.2123808. FASEB J. 1990. PMID: 2123808 Review.
-
The prenylation of proteins.Bioessays. 1992 Jan;14(1):25-31. doi: 10.1002/bies.950140106. Bioessays. 1992. PMID: 1546978 Review.
-
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein.Science. 1990 Sep 7;249(4973):1133-9. doi: 10.1126/science.2204115. Science. 1990. PMID: 2204115
-
Eukaryotic RAS proteins and yeast proteins with which they interact.Curr Top Microbiol Immunol. 1989;147:155-69. doi: 10.1007/978-3-642-74697-0_5. Curr Top Microbiol Immunol. 1989. PMID: 2695293 Review. No abstract available.
-
A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase.Proc Natl Acad Sci U S A. 1995 May 23;92(11):5008-11. doi: 10.1073/pnas.92.11.5008. Proc Natl Acad Sci U S A. 1995. PMID: 7761439 Free PMC article.
Cited by
-
The Biomedical Importance of the Missing Pathway for Farnesol and Geranylgeraniol Salvage.Molecules. 2022 Dec 8;27(24):8691. doi: 10.3390/molecules27248691. Molecules. 2022. PMID: 36557825 Free PMC article. Review.
-
Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes.Nanomedicine. 2021 Oct;37:102439. doi: 10.1016/j.nano.2021.102439. Epub 2021 Jul 10. Nanomedicine. 2021. PMID: 34256063 Free PMC article.
-
Early Stages of Drug Discovery in an Academic Institution and Involvement of Pharma for Advancing Promising Leads.ACS Infect Dis. 2021 Jul 9;7(7):1874-1876. doi: 10.1021/acsinfecdis.1c00091. Epub 2021 Apr 19. ACS Infect Dis. 2021. PMID: 33871981 Free PMC article.
-
Epimerization-free access to C-terminal cysteine peptide acids, carboxamides, secondary amides, and esters via complimentary strategies.Chem Sci. 2017 Nov 9;9(2):350-355. doi: 10.1039/c7sc03553e. eCollection 2018 Jan 14. Chem Sci. 2017. PMID: 29629104 Free PMC article.
-
Selective Gas-Phase Oxidation and Localization of Alkylated Cysteine Residues in Polypeptide Ions via Ion/Ion Chemistry.J Proteome Res. 2016 Sep 2;15(9):3139-46. doi: 10.1021/acs.jproteome.6b00266. Epub 2016 Aug 18. J Proteome Res. 2016. PMID: 27476698 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
