Extraosseous osteosarcoma in the neck

Auris Nasus Larynx. 2012 Jun;39(3):333-6. doi: 10.1016/j.anl.2011.07.014. Epub 2011 Aug 27.


Background: Extraosseous osteosarcoma arising in the head and neck region is an exceptional finding, with a few isolated cases informed in the literature. We report a new case of a large high-grade extraosseous osteosarcoma located in the neck.

Case presentation: A 74 year-old woman with a tumor on the right side of the neck was treated by complete surgical resection. The histopathological diagnosis was osteoblastic extraosseous osteosarcoma. PET-CT scan disclosed no evidence of disease in other areas. Patient received adjuvant radiotherapy and after 3 months of follow-up tumor activity was detected in the cavernous sinus and the patient died of disease one month later.

Conclusion: Extraosseous osteosarcoma in head and neck region is exceptional, and incisional biopsy is the only method to establish a diagnosis and the one to differentiate it from other bone-producing soft tissue tumors. Surgery is the gold standard for treatment of extraosseous osteosarcoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Combined Modality Therapy
  • Fatal Outcome
  • Female
  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / therapy
  • Humans
  • Neck / surgery
  • Osteosarcoma / pathology*
  • Osteosarcoma / therapy
  • Radiotherapy, Adjuvant