Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5715-8. doi: 10.1016/j.bmcl.2011.08.023. Epub 2011 Aug 8.

Abstract

Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3-6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP(+) (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Methyl-4-phenylpyridinium / toxicity
  • Animals
  • Cell Line, Tumor
  • Cell Survival
  • Coleoptera / microbiology
  • Dopamine / metabolism
  • Drug Discovery
  • Molecular Structure
  • Neuroblastoma
  • Neuroprotective Agents / chemistry*
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / pharmacology*
  • Neuroprotective Agents / toxicity
  • Neurotoxicity Syndromes* / drug therapy
  • Neurotoxicity Syndromes* / prevention & control
  • Oximes / chemistry*
  • Oximes / isolation & purification
  • Oximes / pharmacology*
  • Oximes / toxicity
  • Parkinsonian Disorders / drug therapy
  • Parkinsonian Disorders / prevention & control
  • Pyridines / chemistry*
  • Pyridines / isolation & purification
  • Pyridines / pharmacology*
  • Pyridines / toxicity
  • Streptomyces / chemistry*

Substances

  • Neuroprotective Agents
  • Oximes
  • Pyridines
  • coprismycin A
  • 1-Methyl-4-phenylpyridinium
  • Dopamine