Germline BAP1 Mutations Predispose to Malignant Mesothelioma

Nat Genet. 2011 Aug 28;43(10):1022-5. doi: 10.1038/ng.912.

Abstract

Because only a small fraction of asbestos-exposed individuals develop malignant mesothelioma, and because mesothelioma clustering is observed in some families, we searched for genetic predisposing factors. We discovered germline mutations in the gene encoding BRCA1 associated protein-1 (BAP1) in two families with a high incidence of mesothelioma, and we observed somatic alterations affecting BAP1 in familial mesotheliomas, indicating biallelic inactivation. In addition to mesothelioma, some BAP1 mutation carriers developed uveal melanoma. We also found germline BAP1 mutations in 2 of 26 sporadic mesotheliomas; both individuals with mutant BAP1 were previously diagnosed with uveal melanoma. We also observed somatic truncating BAP1 mutations and aberrant BAP1 expression in sporadic mesotheliomas without germline mutations. These results identify a BAP1-related cancer syndrome that is characterized by mesothelioma and uveal melanoma. We hypothesize that other cancers may also be involved and that mesothelioma predominates upon asbestos exposure. These findings will help to identify individuals at high risk of mesothelioma who could be targeted for early intervention.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asbestos / toxicity
  • Environmental Exposure
  • Female
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Germ-Line Mutation*
  • Humans
  • Male
  • Melanoma / genetics
  • Mesothelioma / genetics*
  • Mesothelioma / pathology
  • Pedigree
  • Pleural Neoplasms / genetics*
  • Pleural Neoplasms / pathology
  • Risk Factors
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / metabolism
  • Ubiquitin Thiolesterase / genetics*
  • Ubiquitin Thiolesterase / metabolism
  • Uveal Neoplasms / genetics

Substances

  • BAP1 protein, human
  • Tumor Suppressor Proteins
  • Asbestos
  • Ubiquitin Thiolesterase

Supplementary concepts

  • Uveal melanoma