Integrating developmental signals: a Hippo in the (path)way

Oncogene. 2012 Apr 5;31(14):1743-56. doi: 10.1038/onc.2011.363. Epub 2011 Aug 29.


The Hippo pathway, a signaling cascade that controls cell cycle progression, apoptosis and cell differentiation, has emerged as a fundamental regulator of many physiological and pathological processes. Recent studies have revealed a complex network of interactions directing Hippo pathway activity, and have connected this pathway with other key signaling pathways. Such crosstalk has uncovered novel roles for Hippo signaling, including regulation of TGFβ/SMAD and WNT/β-catenin pathways. This review highlights some of the recent findings in the Hippo field with an emphasis on how the Hippo pathway is integrated with other pathways to mediate diverse processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle Proteins
  • Drosophila Proteins / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Nuclear Proteins / metabolism
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction / physiology
  • Transcription Factors / metabolism
  • Transforming Growth Factor beta / metabolism
  • Wnt Proteins / metabolism


  • Cell Cycle Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • TAZ protein, human
  • Transcription Factors
  • Transforming Growth Factor beta
  • Wnt Proteins
  • YY1AP1 protein, human
  • Protein-Serine-Threonine Kinases
  • hpo protein, Drosophila